Hypertension, Platelets, and Inflammatory Responses
نویسندگان
چکیده
منابع مشابه
Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases.
Platelets are essential for physiological hemostasis and are central in pathological thrombosis. These are their traditional and best known activities in health and disease. In addition, however, platelets have specializations that broaden their functional repertoire considerably. These functional capabilities, some of which are recently discovered, include the ability to sense and respond to i...
متن کاملHypertension, Platelets, and the Endothelium
Platelets are the smallest of the blood cells, yet they are one of the main players during the process of thrombus formation (thrombogenesis). Furthermore, the traditional belief that the endothelium exists simply to provide an inert interface between the blood and the vessel wall is no longer accurate. Indeed, the endothelium produces a large number of substances that affect blood flow and in ...
متن کاملNovel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction.
OBJECTIVE The goal of this study was to investigate the role of platelets in systemic and cardiac inflammatory responses and the development of postinfarct ventricular complications, as well as the efficacy of antiplatelet interventions. METHODS AND RESULTS Using a mouse myocardial infarction (MI) model, we determined platelet accumulation and severity of inflammation within the infarcted myo...
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Atherosclerosis is an inflammatory disease. Platelets can "inflame" the vascular wall by various mechanisms and thereby initiate and support the development of atherosclerosis. Platelet interaction with leukocytes, endothelial cells, and circulating progenitor cells triggers autocrine and paracrine activation processes, leading to inflammatory and atherogenic cascades at the vascular wall. This...
متن کاملPlatelets: unindicted coconspirators in inflammatory tissue injury.
In the 1970s, during the peak of eicosanoid research, platelets were generally considered to play a major role in mediating the cell and tissue injury known to occur in cerebral ischemia/stroke, myocardial ischemia/infarction, and traumatic injury to other organs or regions. Foremost among the platelet-derived humoral mediators of this type of tissue injury were the prostaglandins (eg, PGF2a), ...
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ژورنال
عنوان ژورنال: Cardiovascular Drugs and Therapy
سال: 2014
ISSN: 0920-3206,1573-7241
DOI: 10.1007/s10557-014-6508-y